| 标题 |
 Hepatitis-Associated Aplastic Anemia: Etiology, Clinical Characteristics and Outcome 相关领域
医学
全血细胞减少症
细胞减少
再生障碍性贫血
外科
病因学
内科学
胃肠病学
丙型肝炎
骨髓
肝炎
贫血
骨髓衰竭
造血
干细胞
生物
遗传学
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| 网址 | |
| DOI | |
| 其它 |
Abstract Hepatitis-associated aplastic anemia (HAA) is a form of acquired aplastic anemia (AA) in which bone marrow failure develops after an acute attack of hepatitis. Bone marrow failure leading to AA is generally severe in cases of HAA and fatal if left untreated. This retrospective multicenter study investigated clinical and laboratory characteristics, possible causes, treatment, and outcome of HAA in children. Twenty patients from 8 centers were included in the study. Aspartate aminotransferase and alanine aminotransferase were <3 to 5×upper limit of normal (ULN) in 2 patients, <5 to 10×ULN in 2 patients, and >10×ULN in 16 patients. Acute liver failure developed in 5 (29%) patients. Pancytopenia was simultaneously present in 6 of 20 (30%) patients. Eleven of the 20 patients (55%) were alive, in remission and transfusion free. Those who were alive either had undergone hematopoietic stem cell transplantation and/or immunosuppressive treatment, …… |
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2022-05-21 10:39:56 发布，悬赏 20 积分
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