| 标题 |
 Targeting the epigenetic regulation of antitumour immunity 靶向抗肿瘤免疫的表观遗传调控
相关领域
表观遗传学
表观基因组
表观遗传学
表观遗传疗法
免疫原性
癌症
免疫疗法
DNA甲基化
组蛋白
免疫系统
生物
免疫学
癌症研究
遗传学
基因表达
基因
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Simon J. Hogg, Paul A. Beavis, Mark A. Dawson & Ricky W. Johnstone Nature Reviews Drug Discovery volume 19, 355 Citations 39 Altmetric Metricsdetails Abstract Dysregulation of the epigenome drives aberrant transcriptional programmes that promote cancer onset and progression. Although defective gene regulation often affects oncogenic and tumour-suppressor networks, tumour immunogenicity and immune cells involved in antitumour responses may also be affected by epigenomic alterations. This could have important implications for the development and application of both epigenetic therapies and cancer immunotherapies, and combinations thereof. Here, we review the role of key aberrant epigenetic processes — DNA methylation and post-translational modification of histones — in tumour immunogenicity, as well as the effects of epigenetic modulation on antitumour immune cell function. |
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