| 标题 |
 Oncostatin M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells 抑瘤素M刺激人肝癌HepG2细胞IL-6受体的表达和释放
相关领域
肿瘤抑制因子
受体
化学
跨膜蛋白
地塞米松
细胞生物学
内分泌学
内科学
分子生物学
白细胞介素6
生物
生物化学
细胞因子
免疫学
医学
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| 其它 | 摘要：Soluble IL-6R (sIL-6R), which lacks the transmembrane domain, has been suggested to be a potent immunomodulator of IL-6 biologic activity. In this study, the ability of tells of hepatic origin to generate the sIL-6R was investigated, It was found that oncostatin M alone or in combination with the glucocorticoid analogue dexamethasone significantly up-regulated. IL-6R release, Oncostatin M appeared to generate the sIL-6A primarily through an alternative splicing mechanism. Since sIL-6R is able to form biologically active complexes with IL-6, the release of the sIL-6R from hepatocytes may be important to sensitize cells lacking the membrane-bound receptor, particularly during an acute phase reaction. |
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