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Applications of Decellularized Extracellular Matrix for Regenerative Medicine
脱细胞细胞外基质在再生医学中的应用
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Abstract With a three-dimensional connective fiber network, the decellularized extracellular matrix (dECM), which is composed of various proteins, glycosaminoglycans, proteoglycans, collagens, and elastin, has been shown to play critical roles in supporting cells as well as provide the metabolic site for cells. However, the application for tissue repair of dECM is limited owing to the source of dECM and the lack of bioactive molecules. The combination of stem cells and decellularized materials will affect the differentiation of stem cells and regulate the function of stem cells by microenvironmental factors. In this chapter, we will focus on the current understanding of the characteristics and therapeutic mechanisms of dECM and discuss various decellularized methods of multiple organs. Finally, we will provide a detailed introduction of existing processes in the implementation of dECM with stem cells to alleviate skin, cartilage, heart, kidney, liver, lung, and dental pulp injuries. |
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