| 标题 |
A culturally tailored anti-inflammatory diet for Hispanic patients with ulcerative colitis
西班牙裔溃疡性结肠炎患者的文化定制抗炎饮食
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| 其它 |
O. M. Damas 2024 Accession Number: GRANTS:17810547 PROJECT SUMMARYUlcerative colitis (UC) is on the rise globally, including among Hispanic/Latinos (H/L). Despite growing evidenceof the importance of diet in UC, few clinical trials have examined the impact of diet on inflammation–especiallyamong H/L. The long-term goal of our team is to develop evidence-based, personalized dietary treatments forUC that consider individual patient-factors including cultural food preferences to improve both diseaseinflammation and adherence. From our pilot data, we have evidence that cultural, native diets may help todecrease disease inflammation compared to Western diets and that stool microbiome signatures may provideguidance on future flares. We also have pilot data from my K23 cohort suggesting that H/L patients with UC carrypolyunsaturated fatty acids (PUFA) pathway genetic variants in enzymes that alter the imbalance of n-6 to n-3PUFA ratios in the blood and tissues. |
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