| 标题 |
 “Angular” Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery “角”螺环氮杂环丁烷：药物发现中的合成、表征和评价
相关领域
吗啉
哌嗪
药物发现
立体化学
药品
组合化学
医学
药理学
化学
有机化学
生物化学
|
| 网址 | |
| DOI | |
| 其它 |
Abstract The previously neglected “angular” spirocyclic azetidines have been synthesized, characterized, and validated in drug discovery. We have shown that these compounds could act as bioisosteres for common saturated six-membered heterocycles. Their incorporation into the structure of the anticancer drug Sonidegib (instead of morpholine), and Danofloxacine (instead of piperazine) provided novel patent-free analogs with similar physicochemical properties and high activity. |
| 求助人 | |
| 下载 | 该求助完结已超 24 小时，文件已从服务器自动删除，无法下载。 |
|
温馨提示：该文献已被科研通 学术中心 收录，前往查看
科研通『学术中心』是文献索引库，收集文献的基本信息（如标题、摘要、期刊、作者、被引量等），不提供下载功能。如需下载文献全文，请通过文献求助获取。
|
毛豆
Yifan2024
ceeray23
cocolu
SYLH
藤椒辣鱼
bruna
Chillichee
杳鸢
从容的无极
Holy
IlIIlIlIIIllI
IIIIIllllIIII
xiaxiao
33
MchemG
剑指东方是为谁
无名老大
Lucas
tursun
皖公网安备34019202002308
