| 标题 |
[高分]
 Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects 美洛昔康对健康受试者血小板环氧化酶-1和单核细胞环氧化酶-2的剂量依赖性抑制作用
相关领域
美洛昔康
环氧合酶
全血
单核细胞
血栓素B2
药理学
血小板
化学
前列腺素
医学
血栓素
体内
内科学
内分泌学
酶
生物化学
生物
生物技术
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| 网址 | |
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| 其它 |
期刊：PubMed 作者：Maria R. Panara; Giulia Renda; Maria G. Sciulli; Giovanna Santini; Maria di Giamberardino; et al 出版日期：1999-07-01 Abstract We evaluated whether therapeutic blood levels of meloxicam are associated with selective inhibition of monocyte cyclooxygenase (COX)-2 in vitro and ex vivo. Concentration-response curves for the inhibition of monocyte COX-2 and platelet COX-1 were obtained in vitro after the incubation of meloxicam with whole blood samples. Moreover, 11 healthy volunteers received placebo or 7.5 or 15 mg/day meloxicam, each treatment for 7 consecutive days, according to a randomized, double-blind, crossover design. Before dosing and 24 h after the seventh dose of each regimen, heparinized whole blood samples were incubated with lipopolysaccharide (10 microgram/ml) for 24 h at 37 degrees C, and prostaglandin E2 was measured in plasma as an index of monocyte COX-2 activity. |
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