| 标题 |
Sex specific differences in intestinal radiosensitivity
肠道放射敏感性的性别特异性差异
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| DOI |
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| 其它 | Project SummaryRole of sex as a confounder in radiation research and its implication in radiological and nuclear countermeasuredevelopment has not been addressed well. Currently, there is a need for strategies that mitigate Gastrointestinalacute radiation syndrome (GI-ARS). However, sex specific differences in intestinal radiosensitivity have not beendetermined. Intestinal epithelium is one of the most radiosensitive tissue due to their high self-renewal rate.Radiation-induced damage in intestinal epithelium results in loss of crypt progenitor cells, damage of crypt villusstructure resulting in impaired mucosal barrier function, inflammation, bacterial influx and sepsis. |
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