| 标题 |
Poecillasirin A: A new tri-indole alkaloid from a deep water Poecillastra sp
Poecillasirin A：来自深水Poecillastra sp的一种新的三吲哚生物碱
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| 其它 | ABSTRACT:Antibacterial-guided fractionation of the deep-water marine sponge Poecillastra sp. led to the isolation of two new indole alkaloids poecillasirin A (1) and poecillasirinol (2), along with two known analogs spongotine C and dibromodeoxytopsentin. Their planar structures were determined by 1D and 2D NMR spectroscopy. Their absolute configurations were determined through a combination of exptl. and computational analyses. Poecillasirin A (1) represents the first example of a di(6-Br-1H-indol-3-yl)methyl group linked to an imidazole core. The presence of alc. 2 suggested a biosynthetic route to tri-indole 1. All of the compounds showed strong antimicrobial activity against Staphylococcus aureus, but no inhibitory effect on Escherichia coli. Their anti-HIV activity was also evaluated. |
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