| 标题 |
[Molecular Mechanism of Action of hnRNP K and RTN3 in the Replication of Enterovirus 71]
[hnRNP K和RTN3在肠道病毒71复制中的分子作用机制]
相关领域
肠道病毒71
生物
核糖核酸
病毒学
病毒复制
微小病毒
翻译（生物学）
肠道病毒
病毒
基因
遗传学
信使核糖核酸
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AI链接 nih.gov |
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| 其它 | Enterovirus 71 (EV71) is a neurotropic pathogen that can induce hand, foot and mouth disease in children. There is an appreciable mortality rate after EV71 infections. The mechanism of action of EV71 replication is not known. Recent work has identified some of cell factors of the host that participate in the synthesis of the RNA and proteins of EV71 (e.g., hnRNP K, reticulon 3 (RTN 3)). In that work, researchers used a competitive assay to show that hnRNP K can interact with EV71 5' UTR, which is required for efficient synthesis of viral RNA. Using a yeast two-hybrid system, other researchers demonstrated that RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. Here, we discuss recent work focusing on the molecular mechanisms of hnRNP K and RTN 3 in the synthesis of the RNA and proteins of EV71. |
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