| 标题 |
 Population pharmacokinetics and pharmacogenetics of apatinib in adult cancer patients 成人癌症患者阿帕替尼的群体药代动力学和药物遗传学研究
相关领域
阿帕蒂尼
CYP3A5
医学
药代动力学
癌症
人口
肿瘤科
内科学
药物遗传学
药理学
基因型
生物
遗传学
环境卫生
基因
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Abstract Aims: Apatinib is widely used in Chinese cancer patients. As the in vivo drug disposition of apatinib has large individual differences, adverse events are prone to occur. Cytochrome P450 (CYP)3A5 and cancer types maybe the main factors affecting this individual differences. The objective of our study was to establish a population pharmacokinetics (PK) model of apatinib in adult cancer patients, and to explore optimal dosage regimens for individualized treatment. Methods: Adult patients with various types of cancer treated with apatinib were enrolled. The concentration of apatinib in plasma was determined by high-performance liquid chromatography-tandem mass spectrometry. CYP3A5 genotype was determined using TaqMan allelic discrimination technique. The population PK model was developed by NONMEM V7.4. The dosing regimen was optimized based on Monte Carlo simulations. |
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