| 标题 |
 Comparison of Biologics and Oral Treatments for Plaque Psoriasis: A Meta-analysis 生物制剂与口服治疗斑块型银屑病的Meta分析
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| 网址 | |
| DOI |
10.1001/jamadermatol.2019.4029
doi
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| 其它 |
ArmstrongAWetal.JAMADermatol.2020;156(3):258–269. Question What is the short-term and long-term comparative efficacy among biologics and oral agents for plaque psoriasis? Findings In a network meta-analysis of 60 clinical trials for short-term efficacy, brodalumab, guselkumab, ixekizumab, and risankizumab-rzaa had the highest Psoriasis Area and Severity Index response rates at 10 to 16 weeks from baseline. A meta-analysis of long-term efficacy suggested that brodalumab, guselkumab, ixekizumab, and risankizumab-rzaa had the highest response rates at 44 to 60 weeks. Meaning This study provides an assessment of both short-term and long-term comparative efficacy among treatments for moderate to severe plaque psoriasis which can help health care stakeholders optimize treatment regimens. |
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