| 标题 |
uestioning the safety of widespread ppi prescribing in older adults
质疑老年人广泛使用ppi的安全性
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| 其它 | Introduction: Proton pump inhibitors (PPIs) are very commonly prescribed and are often continued with multiple co-morbidities, polypharmacy and into very old age. There is currently limited evidence regarding safety of PPIs at advanced ages, with multimorbid-ity and with commonly co-prescribed drugs. We conducted 3 cohort studies to estimate community acquired pneumonia after the acute prescription period, fracture risk and vascular risk in older adults exposed to longer term PPIs. Methods: We used data from the Clinical Practice Research Datalink linked to hospital episode statistics in 3 retrospective cohort studies in adults over 60 exposed to PPIs for at least 1 year, using a difference-in-difference methodology (the Prior Event Rate Ratio) and propensity score regression adjustment to enhance the quality of evidence. Year 2 community-acquired pneumonia risk was estimated in 150,100 patients. |
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36456657
毛豆
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Yifan2024
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