| 标题 |
  书籍（章节） Measuring Efflux and Permeability in Mycobacteria 分枝杆菌外排和通透性的测定
相关领域
流出
溴化乙锭
生物
微生物学
单元格信封
细胞壁
细胞质
生物化学
基因
大肠杆菌
DNA
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| 备注 |
第227–239页 核对摘要内容The mycobacterial cell wall is rich in lipids and polysaccharides making a compact envelope that limits drug uptake.
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| 网址 | |
| DOI | |
| 其它 |
期刊：Methods in molecular biology 作者：Liliana Rodrigues; Miguel Viveiros; José A. Aı́nsa 出版日期：2015-01-01 摘要内容包含：The intrinsic resistance of mycobacteria to most antimicrobial agents is mainly attributed to the synergy between their relatively impermeable cell wall and efflux systems. The mycobacterial cell wall is rich in lipids and polysaccharides making a compact envelope that limits drug uptake. Changes in cell wall composition or structure lead to variations in susceptibility to drugs. Bacterial efflux pumps are membrane proteins that are capable of actively transporting a broad range of substrates, including drugs, from the cytoplasm to the extracellular environment. Increased expression of efflux pump genes confers a low level resistance phenotype, and under these conditions, bacteria may have greater chances of acquiring chromosomal mutation(s) conferring higher levels of drug resistance. |
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