亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Pharmacokinetic parameters of terbutaline in healthy man. An overview.

特布他林 药代动力学 分配量 化学 吸收(声学) 半衰期 口服 血浆浓度 分布(数学) 内分泌学 医学 药理学 内科学 材料科学 数学 数学分析 复合材料 哮喘
作者
Lars Nyberg
出处
期刊:PubMed 卷期号:134: 149-60 被引量:47
链接
标识
摘要

After a single intravenous dose, plasma concentrations of terbutaline fall in a multi-exponential manner. The pharmacokinetic parameters are therefore preferably calculated by a non-compartmental method. Not until 6-12 h after an intravenous injection does terbutaline enter a mono-exponential decline phase. Negligence of this behaviour has produced reports of terminal half-lives in the literature, which are large underestimates. Prolonged sampling reveals that the terminal half-life of terbutaline in healthy subjects is about 17 h with an about twofold variation between subjects. This half-life determines, as a mean, about half the total area under the plasma concentration-time curve. Most studies have been performed in male subjects. On average, they have a body clearance of 3.0 mL/min/kg, 2/3 of this being the renal contribution. On a body weight basis, the renal clearance in women is at least as high as in men, possibly somewhat larger. Terbutaline's volume of distribution at steady state averages 1.6 L/kg. The systemic mean residence time of the drug is about 9 h. Terbutaline is little bound to plasma proteins but shows affinity to erythrocytes. However, clearance calculations should probably be based on the plasma concentration, because of a comparatively slow release rate from the erythrocytes. After oral administration, plasma concentration peaks of terbutaline appear within 1-4 h. Food reduces their height by about 40%. Particularly after single doses, more than one concentration peak is observed in plasma. Subjects differ considerably in their oral absorption capacity of the drug; an interindividual range of about 25-80% of the dose can be estimated. This creates a range in the extent of bioavailability of 7-26%, the decrease of the percentages being due to a high first-pass metabolism. There are strong indications that this occurs preferentially in the gut wall. The predominant metabolite of terbutaline formed in man is a sulphate conjugate. Mean bioavailability of oral terbutaline in fasting subjects is 14-15%. Food impairs the bioavailability by about one third because of reduced absorption. Despite the large variation in extent of terbutaline bioavailability between subjects, each individual behaves reproducibly from dose to dose.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
沉默羔羊完成签到,获得积分10
3秒前
shaylie完成签到 ,获得积分10
8秒前
阿九完成签到,获得积分10
15秒前
NanNan626发布了新的文献求助30
22秒前
然463完成签到 ,获得积分10
31秒前
32秒前
Hcc完成签到 ,获得积分10
38秒前
46秒前
风登楼发布了新的文献求助10
51秒前
学术小白完成签到,获得积分10
53秒前
56秒前
婼汐完成签到 ,获得积分10
58秒前
59秒前
量子星尘发布了新的文献求助10
1分钟前
Owen应助瘦瘦的寒珊采纳,获得10
1分钟前
1分钟前
活泼的冬寒完成签到,获得积分10
1分钟前
1分钟前
瘦瘦的寒珊完成签到,获得积分10
1分钟前
有魅力听枫完成签到,获得积分10
1分钟前
1分钟前
叶梓轩完成签到 ,获得积分10
1分钟前
wanci应助如意的书桃采纳,获得30
1分钟前
李健的粉丝团团长应助gyh采纳,获得10
1分钟前
Owen应助风登楼采纳,获得10
1分钟前
1分钟前
xiao发布了新的文献求助10
1分钟前
孙孙应助图治采纳,获得10
1分钟前
风登楼完成签到,获得积分10
1分钟前
香蕉觅云应助xiao采纳,获得10
2分钟前
我啊完成签到 ,获得积分10
2分钟前
木木完成签到 ,获得积分10
2分钟前
开心的火龙果完成签到,获得积分10
2分钟前
西红柿有股番茄味完成签到,获得积分10
2分钟前
量子星尘发布了新的文献求助10
2分钟前
zz完成签到,获得积分10
2分钟前
2分钟前
研友_VZG7GZ应助polaris采纳,获得10
2分钟前
2分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976643
求助须知:如何正确求助?哪些是违规求助? 3520735
关于积分的说明 11204613
捐赠科研通 3257484
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806613