碳酸氢钠
肾上腺素
利多卡因
麻醉
交叉研究
碳酸氢盐
医学
化学
内科学
安慰剂
替代医学
物理化学
病理
作者
Ole Hedeager Momsen,C M Roman,Mohammed Babiker,Göteborg Andersen
出处
期刊:PubMed
日期:2000-08-14
卷期号:162 (33): 4391-4
被引量:13
摘要
The amount of sodium bicarbonate necessary to neutralise commercially available lignocaine-epinephrine (pH 4.7) to physiologically neutral pH (7.4) was established. The analysis showed that neutral pH could be accomplished by adding 1.0 ml sodium bicarbonate (8.4 g/l) to 10 ml lignocaine-epinephrine (1%, 5 microgram/ml). Chemical analysis also established that the neutralised lignocaine-epinephrine was stable for 24 hours after adding sodium bicarbonate. A double-blinded randomised clinical trial with crossover design done on volunteers from hospital staff proved that injection of neutralised lignocaine-epinephrine is less painful than commercially available lignocaine-epinephrine (p < 0.001).
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