镰状细胞性贫血
β地中海贫血
血红蛋白病
血红蛋白变体
BETA(编程语言)
疾病
细胞
血红蛋白
医学
地中海贫血
β地中海贫血
溶血性贫血
儿科
内科学
遗传学
生物
计算机科学
程序设计语言
作者
Piera Samperi,S. P. Dibenedetto,Andrea Di Cataldo,Giovanna Russo,G. Schilirò
出处
期刊:PubMed
日期:1990-09-01
卷期号:75 (5): 464-6
被引量:3
摘要
In Italy sickle cell disease is mainly represented by sickle cell anemia (beta s/beta s) and sickle cell thalassemia (beta s/beta oth or beta s/beta+ th). Association of Hb S with other beta variants has been observed in other ethnic groups. Since some of these variants have electrophoretic mobility at alkaline pH similar to Hb S, they are frequently misinterpreted as Hb S in the homozygote state. This paper reports the first case of Hb S/Hb D-Los Angeles observed in Italy. The authors underline the need to perform accurate and specific tests in all patients with sickle cell disease and available relatives, in order to exclude combinations of Hb S with other beta hemoglobin variants.
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