细胞毒性T细胞
启动(农业)
生物
抗原
免疫系统
免疫学
CTL公司*
抗原呈递
抗原提呈细胞
免疫监视
免疫疗法
免疫原性细胞死亡
癌症免疫疗法
CD8型
T细胞
体外
发芽
植物
生物化学
作者
Carlos Luri‐Rey,Gabriel Gomis,Javier Glez‐Vaz,Almudena Manzanal,Ana Martínez‐Riaño,Maria E. Rodriguez Ruiz,Álvaro Teijeira,Ignacio Melero
摘要
Summary Antigen cross‐priming of CD8 + T cells is a critical process necessary for the effective expansion and activation of CD8 + T cells endowed with the ability to recognize and destroy tumor cells. The cross‐presentation of tumor antigens to cross‐prime CD8 + T cells is mainly mediated, if not only, by a subset of professional antigen‐presenting cells termed type‐1 conventional dendritic cells (cDC1). The demise of malignant cells can be immunogenic if it occurs in the context of premortem stress. These ways of dying are termed immunogenic cell death (ICD) and are associated with biochemical features favoring cDC1 for the efficient cross‐priming of tumor antigens. Immunosurveillance and the success of immunotherapies heavily rely on the ability of cytotoxic immune cells, primarily CD8 + T cells and NK cells, to detect and eliminate tumor cells through mechanisms collectively known as cytotoxicity. Recent studies have revealed the significance of NK‐ and CTL‐mediated cytotoxicity as a prominent form of immunogenic cell death, resulting in mechanisms that promote and sustain antigen‐specific immune responses. This review focuses on the mechanisms underlying the cross‐presentation of antigens released during tumor cell killing by cytotoxic immune cells, with an emphasis on the role of cDC1 cells. Indeed, cDC1s are instrumental in the effectiveness of most immunotherapies, underscoring the significance of tumor antigen cross‐priming in contexts of immunogenic cell death. The notion of the potent immunogenicity of cell death resulting from NK or cytotoxic T lymphocyte (CTL)‐mediated cytotoxicity has far‐reaching implications for cancer immunotherapy.
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