南极洲假丝酵母
生物催化
化学
酰胺
绿色化学
有机化学
脂肪酶
小学(天文学)
酶
可持续生产
肽键
组合化学
催化作用
离子液体
生产(经济)
物理
天文
经济
宏观经济学
作者
György Orsy,Sayeh Shahmohammadi,Enikő Forró
出处
期刊:Molecules
[MDPI AG]
日期:2023-07-28
卷期号:28 (15): 5706-5706
标识
DOI:10.3390/molecules28155706
摘要
A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis.
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