The virulence of Dichelobacter nodosus, measured by the elastase test, is an important predictor for virulent footrot diagnosis in New South Wales sheep flocks

毒力 羊群 微生物学 生物 脚腐病 胰弹性蛋白酶 弹性蛋白酶 兽医学 医学 基因 生物化学
作者
A. M. Collins,Daniel A. Collins,Om P. Dhungyel
出处
期刊:Australian Veterinary Journal [Wiley]
标识
DOI:10.1111/avj.13295
摘要

Ovine footrot is a contagious bacterial disease that causes foot lesions, and depending on the virulence of the causative strains, may lead to severe underrunning of the hoof and lameness. Virulent footrot can be identified, treated and controlled more effectively than less virulent benign forms. The in vitro elastase test for virulence of the causative bacteria, Dichelobacter nodosus, has been used to support clinical diagnosis. However, not all laboratory-designated virulent D. nodosus strains cause clinical signs of virulent footrot. This study evaluated retrospectively how well the elastase test supported clinical footrot diagnosis in 150 sheep flocks examined for suspect footrot in New South Wales between August 2020 and December 2021. Flocks were included if measures of clinical disease, environmental conditions and the virulence of D. nodosus isolates were available. Variation in the elastase activity result between D. nodosus isolated from the same flock made bacterial virulence hard to interpret, but calculating the mean elastase rate for all isolates from the same flock made correlations between bacterial virulence and flock footrot diagnosis possible. Simplifying bacterial virulence into whether there were any elastase-positive D. nodosus isolates before 12 days increased the predictive value of elastase results for virulent diagnosis, compared with using the first day that any isolate was elastase positive or the percentage of elastase-positive isolates by 12 days, but not all clinically virulent flocks had isolates with elastase activity before 12 days. Logistic regression models were fitted to identify the minimum number of predictors for virulent footrot diagnosis, with models suggesting that virulent footrot diagnosis was best predicted by adding the elastase test result and environmental conditions to the prevalence of severe foot lesions (score 4 and 5). However, performing the same analysis with different breeds, ages of sheep and seasons might highlight other factors important in the diagnosis of virulent footrot.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yy完成签到,获得积分10
1秒前
峰宝宝完成签到,获得积分10
1秒前
winter发布了新的文献求助10
1秒前
莓啤汽发布了新的文献求助10
2秒前
3秒前
2208完成签到,获得积分10
3秒前
sci发布了新的文献求助10
3秒前
苗苗子子完成签到,获得积分10
3秒前
4秒前
思绪摸摸头完成签到 ,获得积分10
4秒前
4秒前
4秒前
博修发布了新的文献求助10
4秒前
香蕉觅云应助zz采纳,获得10
5秒前
5秒前
5秒前
5秒前
6秒前
仿若浮云完成签到,获得积分10
6秒前
7秒前
7秒前
青青发布了新的文献求助10
8秒前
犹豫梦旋完成签到,获得积分10
8秒前
9秒前
9秒前
123456完成签到,获得积分20
9秒前
9秒前
10秒前
10秒前
科研通AI5应助Candice采纳,获得10
10秒前
容珏完成签到,获得积分10
10秒前
persist发布了新的文献求助10
10秒前
小林发布了新的文献求助10
11秒前
月儿发布了新的文献求助10
11秒前
丘比特应助Yang采纳,获得10
11秒前
12秒前
大大大大管子完成签到 ,获得积分10
12秒前
罗山柳发布了新的文献求助10
12秒前
汉堡包应助莓啤汽采纳,获得10
12秒前
秀丽安波完成签到,获得积分10
12秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Exploring the effects of an evidenced-based professional development programme on teaching and learning in Chinese kindergartens 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3575888
求助须知:如何正确求助?哪些是违规求助? 3145886
关于积分的说明 9462931
捐赠科研通 2847391
什么是DOI,文献DOI怎么找? 1565114
邀请新用户注册赠送积分活动 732817
科研通“疑难数据库(出版商)”最低求助积分说明 719373