Is there a relationship between NOAC and the neutrophil-to-lymphocyte ratio?

Recently, we have read with great interest Dr. Fagundes Jr. and colleagues' article that published in International Journal of Cardiology [ [1] Fagundes A.J. Ruff C.T. Morrow D.A. Murphy S.A. Palazzolo M.G. Chen C.Z. et al. Neutrophil-lymphocyte ratio and clinical outcomes in 19,697 patients with atrial fibrillation: analyses from ENGAGE AF- TIMI 48 trial. Int. J. Cardiol. 2023; 386: 118-124 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar ]. This study demonstrated that the neutrophil-to-lymphocyte ratio (NLR) was associated with elevated bleeding risk, cardiovascular events, and mortality in patients with atrial fibrillation.