地氯酸
金黄色葡萄球菌
清道夫受体
内皮干细胞
微生物学
受体
葡萄球菌感染
生物
蛋白质A
突变体
脂蛋白
抗体
生物化学
免疫学
细菌
体外
胆固醇
基因
遗传学
作者
Jessica Slavetinsky,Esther Lehmann,Christoph Slavetinsky,Lisa Gritsch,Rob van Dalen,Dorothee Kretschmer,Lisa Bleul,Christiane Wolz,Christopher Weidenmaier,Andreas Peschel
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2023-11-01
卷期号:9 (11): 2133-2140
被引量:2
标识
DOI:10.1021/acsinfecdis.3c00252
摘要
The success of Staphylococcus aureus as a major cause for endovascular infections depends on effective interactions with blood-vessel walls. We have previously shown that S. aureus uses its wall teichoic acid (WTA), a surface glycopolymer, to attach to endothelial cells. However, the endothelial WTA receptor remained unknown. We show here that the endothelial oxidized low-density lipoprotein receptor 1 (LOX-1) interacts with S. aureus WTA and permits effective binding of S. aureus to human endothelial cells. Purified LOX-1 bound to isolated S. aureus WTA. Ectopic LOX-1 expression led to increased binding of S. aureus wild type but not of a WTA-deficient mutant to a cell line, and LOX-1 blockage prevented S. aureus binding to endothelial cells. Moreover, WTA and LOX-1 expression levels correlated with the efficacy of the S. aureus-endothelial interaction. Thus, LOX-1 is an endothelial ligand for S. aureus, whose blockage may help to prevent or treat severe endovascular infections.
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