TMBPF-induced neurotoxicity and oxidative stress in zebrafish larvae: impacts on central nervous system development and dopamine neurons

斑马鱼 神经毒性 氧化应激 多巴胺 内分泌干扰物 双酚A 双酚 化学 药理学 多巴胺转运体 抗氧化剂 生物 毒性 内分泌学 内科学 基因 多巴胺能 生物化学 内分泌系统 医学 激素 有机化学 环氧树脂
作者
Mengyuan Liang,Junping Deng,Jie Gu,Jinlai Yang,Feng Gao,Caoxing Huang,Wenzhu Wu
出处
期刊:Ecotoxicology and Environmental Safety [Elsevier]
卷期号:268: 115710-115710
标识
DOI:10.1016/j.ecoenv.2023.115710
摘要

Bisphenol A (BPA), a common bisphenol molecule, is well known in the environment as an endocrine disruptor. Furthermore, BPs (BPA, BPS, BPF, and BPAF) have been shown in recent years to be neurotoxic to zebrafish. Tetramethyl bisphenol F (TMBPF) has recently been introduced as a substitute for bisphenol A (BPA) in various industries, including plastics and food contact coatings. However, a growing number of studies have demonstrated that the toxicity of some BPA substitutes is similar to or even stronger than BPA, posing potential harm to human health and the environment. In this study, we used zebrafish larvae as a model to investigate the neurodevelopmental effects of TMBPF at different concentrations (0, 0.25, 0.5, 1, 2, 4 and 8 mg/L). Our results showed that exposure to TMBPF at concentrations higher than 4 mg/L for 72 h post-fertilization (hpf) resulted in zebrafish mortality, whereas exposure to 2 mg/L for 144 hpf caused deformities. Furthermore, TMBPF exposure inhibited the development of the central nervous system, motor nerves, and dopamine neurons in zebrafish. Real-time polymerase chain reaction (PCR) analysis revealed that TMBPF exposure significantly down-regulated the expression of oxidative stress-related genes (Cu/Zn-SOD, Mn-SOD, and CAT) and neurodevelopmental genes (mbp, gafp, and syn2a), while up-regulated the expression of dopamine-related genes (th1, th2, and dat). Notably, treatment with the antioxidant N-acetylcysteine (NAC) alleviated TMBPF-induced toxicity. NAC can regulate the expression of genes related to oxidative stress, neurodevelopment and dopamine development, and make the nerve development of zebrafish normal. Overall, our research suggested that TMBPF may disrupt the development of the early central nervous system and dopamine neurons, leading to abnormal motor behavior in zebrafish larvae. These results highlight the potential risks associated with the use of TMBPF in various industries and the importance to evaluate its potential risks to human health and the environment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
vivian26发布了新的文献求助10
刚刚
酷波er应助敏子采纳,获得10
2秒前
3秒前
小杜发布了新的文献求助10
4秒前
ZP发布了新的文献求助10
7秒前
AUT9发布了新的文献求助10
7秒前
7秒前
Maestro_S应助lll采纳,获得20
10秒前
10秒前
老子完成签到,获得积分10
10秒前
小蘑菇应助weige采纳,获得10
11秒前
书记发布了新的文献求助10
11秒前
瞬间发布了新的文献求助10
11秒前
善学以致用应助小杜采纳,获得10
12秒前
zzzyyyuuu完成签到 ,获得积分10
13秒前
sss完成签到,获得积分20
13秒前
AUT9完成签到,获得积分10
13秒前
LinglongCai完成签到 ,获得积分10
15秒前
倪莺媛发布了新的文献求助10
15秒前
17秒前
18秒前
桐桐应助顺心的水之采纳,获得10
21秒前
22秒前
23秒前
普萘洛尔完成签到,获得积分10
23秒前
喵子完成签到,获得积分10
26秒前
28秒前
gomm完成签到,获得积分10
29秒前
30秒前
明年发布了新的文献求助10
33秒前
科研通AI2S应助燕祁采纳,获得10
33秒前
qqq完成签到,获得积分10
35秒前
35秒前
二甲酚橙完成签到,获得积分10
36秒前
36秒前
36秒前
38秒前
刘佳灏完成签到,获得积分10
38秒前
CipherSage应助西北望采纳,获得10
40秒前
今后应助善良的小白菜采纳,获得10
40秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3136067
求助须知:如何正确求助?哪些是违规求助? 2786953
关于积分的说明 7779912
捐赠科研通 2443071
什么是DOI,文献DOI怎么找? 1298892
科研通“疑难数据库(出版商)”最低求助积分说明 625244
版权声明 600870