厚壁菌
阿拉伯木聚糖
拟杆菌
肠道菌群
麸皮
生物
发酵
免疫系统
微生物学
脾脏
多糖
双歧杆菌
食品科学
体内
抗性淀粉
免疫学
生物化学
淀粉
乳酸菌
生物技术
原材料
生态学
16S核糖体RNA
基因
作者
Ji Zhang,Ziliang He,Yang He,Jing Xie,Guigui Yang,Zhiqiang Niu,Ting Shen,Li Fu
标识
DOI:10.1016/j.ijbiomac.2023.128283
摘要
Arabinoxylan (AX) is the predominant non-starch polysaccharide in wheat bran, known for its significant immunomodulatory activity. However, existing literature lacks comprehensive studies on AX fermentation by gut microbiota and its subsequent immunomodulatory mechanisms. In the present study, we aimed to investigate the effects of AX on the composition of gut microbiota and the characteristics of its immunomodulatory activity. For this purpose, an in vitro fermentation system and a cyclophosphamide-induced immunosuppressed mouse model were established to explore both the in vitro and in vivo effects of AX on gut microbiota and immune modulation. The results demonstrated that AX was metabolized by gut microbes and in turn to promoting the production of short-chain fatty acids (SCFAs), which concurrently led to a significant decrease in pH. Furthermore, AX treatment significantly changed the microbial composition, elevated the relative abundance of Actinobacteria while reducing that of Bacteroidetes. In the immunosuppressed mice, AX administration improved the thymus and spleen indices, mitigated spleen injury, and bolstered overall immunity. Moreover, AX altered the gut microbiota structure, increasing the abundance of Bacteroidetes and decreasing that of Firmicutes. These findings suggest that wheat bran-derived AX can modulate intestinal microbial composition, improve gut microecology, and enhance host immunity by targeting gut microbiota.
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