Cortical thickness reductions associate with brain network architecture in major depressive disorder

神经科学 心理学 重性抑郁障碍 精神科 认知
作者
Wei Sheng,Qian Cui,Yuanhong Guo,Qin Tang,Yun‐Shuang Fan,Chong Wang,Jing Guo,Fengmei Lu,Zongling He,Huafu Chen
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:347: 175-182 被引量:1
标识
DOI:10.1016/j.jad.2023.11.037
摘要

Cortical thickness reductions in major depressive disorder are distributed across multiple regions. Research has indicated that cortical atrophy is influenced by connectome architecture on a range of neurological and psychiatric diseases. However, whether connectome architecture contributes to changes in cortical thickness in the same manner as it does in depression is unclear. This study aims to explain the distribution of cortical thickness reductions across the cortex in depression by brain connectome architecture. Here, we calculated a differential map of cortical thickness between 110 depression patients and 88 age-, gender-, and education level-matched healthy controls by using T1-weighted images and a structural network reconstructed through the diffusion tensor imaging of control group. We then used a neighborhood deformation model to explore how cortical thickness change in an area is influenced by areas structurally connected to it. We found that cortical thickness in the frontoparietal and default networks decreased in depression, regional cortical thickness changes were related to reductions in their neighbors and were mainly limited by the frontoparietal and default networks, and the epicenter was in the prefrontal lobe. Current findings suggest that connectome architecture contributes to the irregular topographic distribution of cortical thickness reductions in depression and cortical atrophy is restricted by and dependent on structural foundation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_VZG7GZ应助景宛白采纳,获得10
刚刚
gy发布了新的文献求助10
刚刚
Went完成签到,获得积分10
1秒前
病毒遗传学完成签到,获得积分10
1秒前
虚幻的黄蜂完成签到 ,获得积分10
2秒前
xxx完成签到 ,获得积分10
2秒前
好好学习完成签到,获得积分10
2秒前
清风完成签到,获得积分10
2秒前
2秒前
乐乐应助天意如此采纳,获得10
2秒前
Li完成签到,获得积分10
2秒前
多情的山水完成签到 ,获得积分10
3秒前
glay完成签到 ,获得积分10
3秒前
溏心发布了新的文献求助20
3秒前
冬瓜发布了新的文献求助10
3秒前
4秒前
张怡乐发布了新的文献求助10
4秒前
艾迪富富完成签到,获得积分10
5秒前
清风发布了新的文献求助10
5秒前
壹贰完成签到,获得积分10
5秒前
兴奋的定帮应助云微颖采纳,获得10
6秒前
tong完成签到,获得积分10
6秒前
Ripples完成签到,获得积分10
8秒前
8秒前
zmuzhang2019完成签到,获得积分10
8秒前
寄居蟹完成签到,获得积分10
8秒前
LHZ完成签到,获得积分10
9秒前
YZJing完成签到,获得积分10
9秒前
情怀应助时尚俊驰采纳,获得10
9秒前
ssjk发布了新的文献求助10
9秒前
Ceaser完成签到,获得积分10
9秒前
万能图书馆应助hzt采纳,获得10
10秒前
10秒前
明亮飞双完成签到,获得积分10
11秒前
虚拟的凡波完成签到,获得积分10
11秒前
可靠若云完成签到,获得积分10
12秒前
魏曼柔完成签到,获得积分10
12秒前
快乐大炮给快乐大炮的求助进行了留言
12秒前
Dudidu完成签到,获得积分10
13秒前
搜集达人应助子衿采纳,获得10
13秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009429
求助须知:如何正确求助?哪些是违规求助? 3549323
关于积分的说明 11301690
捐赠科研通 3283833
什么是DOI,文献DOI怎么找? 1810413
邀请新用户注册赠送积分活动 886275
科研通“疑难数据库(出版商)”最低求助积分说明 811301