Distinct subsets of Vδ1 effector and Vδ2 γδ T cells shift in frequency and are linked to plasma inflammatory markers during ART-suppressed HIV infection

CD38 效应器 提吉特 CD8型 流式细胞术 免疫学 先天免疫系统 CD16 生物 免疫系统 炎症 T细胞 免疫分型 细胞生物学 CD3型 干细胞 川地34
作者
Riley Pihl,Erika L. Smith-Mahoney,Alex Olson,Rachel Yuen,Archana Asundi,Nina Lin,Anna C. Belkina,Jennifer Snyder‐Cappione
出处
期刊:The Journal of Infectious Diseases [Oxford University Press]
标识
DOI:10.1093/infdis/jiae091
摘要

Chronic inflammation is prevalent with ART-suppressed HIV-infection and one immune cell subset putatively driving this phenomenon is TIGIT + γδ T cells.To elucidate γδ T cell phenotypic diversity, spectral flow cytometry was performed on blood lymphocytes from individuals of an HIV and Aging cohort and data were analyzed using bioinformatic platforms. Plasma inflammatory markers were measured and correlated with γδ T cell subset frequencies.39 distinct γδ T cell subsets were identified (22 Vδ1+, 14 Vδ2+, and three Vδ1-Vδ2-Vγ9+) and TIGIT was nearly exclusively found on the Vδ1+ CD45RA+ CD27- 'effector' populations. People living with ART-suppressed HIV-infection (PLWH) exhibited high frequencies of distinct clusters of Vδ1+ effectors distinguished via CD8, CD56, CD16, and CD38 expression. Among Vδ2+ cells, most Vγ9+ ('innate-effector') clusters were lower in PLWH, yet CD27+ subsets were similar in frequency between participants with and without HIV. Comparisons by age revealed lower 'naïve' Vδ1 + CD45RA+ CD27+ in older individuals, regardless of HIV status. Plasma inflammatory markers were selectively linked to subsets of Vδ1+ and Vδ2+ cells.These results further elucidate γδ T cell subset complexity and reveal distinct alterations and connections with inflammatory pathways of Vδ1+ effector and Vδ2+ innate-effector subsets with ART-suppressed HIV infection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
刚刚
852应助大意的砖家采纳,获得10
1秒前
科研通AI5应助hhxyhjh采纳,获得30
2秒前
嘿嘿江完成签到 ,获得积分10
5秒前
勤恳的仰发布了新的文献求助10
5秒前
6秒前
7秒前
emma发布了新的文献求助10
9秒前
Ava应助博修采纳,获得10
9秒前
周稅发布了新的文献求助10
10秒前
10秒前
13秒前
充电宝应助lidongxing采纳,获得30
14秒前
15秒前
15秒前
15秒前
酷波er应助recovery采纳,获得10
16秒前
16秒前
18秒前
hhxyhjh发布了新的文献求助30
20秒前
Andrea完成签到,获得积分20
21秒前
大个应助生动日记本采纳,获得10
21秒前
长隆完成签到,获得积分0
23秒前
23秒前
23秒前
李爱国应助生动丑采纳,获得10
23秒前
YamDaamCaa应助苏卿采纳,获得30
24秒前
25秒前
YamDaamCaa应助苏卿采纳,获得30
27秒前
大模型应助长隆采纳,获得10
27秒前
28秒前
da发布了新的文献求助10
28秒前
李爱国应助Jieh采纳,获得10
29秒前
小蘑菇应助微笑的千凡采纳,获得10
29秒前
月下荷花发布了新的文献求助10
31秒前
32秒前
33秒前
小小肖发布了新的文献求助10
34秒前
iNk应助科研通管家采纳,获得20
34秒前
小蘑菇应助科研通管家采纳,获得10
34秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3979704
求助须知:如何正确求助?哪些是违规求助? 3523700
关于积分的说明 11218393
捐赠科研通 3261224
什么是DOI,文献DOI怎么找? 1800490
邀请新用户注册赠送积分活动 879113
科研通“疑难数据库(出版商)”最低求助积分说明 807182