The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study

医学 脱发 乳腺癌 化疗 不利影响 入射(几何) 回顾性队列研究 头皮 内科学 癌症 临床终点 外科 单变量分析 皮肤病科 临床试验 多元分析 物理 光学
作者
Mangesh Mekha,Ashish Joshi,Vashishth Maniar,Udip Maheshwari,Kshitij Joshi,Pritam Kalaskar,Smit Sheth,Pradip Kendre,Dr Disha Morzaria,Reshma Korgavkar,Chandrashekhar Pethe,Sonal Dhande
出处
期刊:Indian Journal of Dermatology [Medknow Publications]
卷期号:69 (1): 16-23
标识
DOI:10.4103/ijd.ijd_345_23
摘要

Abstract Aim: Chemotherapy-induced alopecia (CIA) is the most common side effect of systemic treatment in breast cancer patients. Scalp cooling gained worldwide acceptance in preventing or mitigating CIA in patients undergoing chemotherapy. The objective of this study was to evaluate the efficacy and safety of the Paxman scalp cooling system (PSCS) in Indian breast cancer patients. Materials and Methods: This is a multi-centre, retrospective-observational study including patients registered from 1 st March, 2019 to 30 th April, 2021 undergoing chemotherapy for breast cancer by using PSCS. The primary end-point was the incidence of CIA after completing cycles of chemotherapy. Results: A total of 91 female patients were enrolled in the study, with a median age of 53 years (IQR: 44–62 years). The prevention of alopecia (grade 0 and grade I) was seen in 81%, while more than 50% hair loss (grade 2) was seen in 16.48% after completion of treatment. The univariate analysis results showed that CIA was significantly higher in patients who received anthracyclines (OR: 2.69; 95% CI: 1.04–6.958; P = 0.041) and in patients with a post-infusion cooling time of >150 minutes (OR: 8.409; 95% CI: 2.295–30.787; P = 0.001). The incidence of grade 2 (>50% hair loss) alopecia was 81.3% in patients <6 weeks and was 18.8% at >6 weeks of start of chemotherapy ( P < 0.0001). No adverse events were reported in 71.4% of patients, and the most common adverse event was headache (18.7%). Conclusion: PSCS is an effective and well-tolerated treatment modality for preventing CIA among breast cancer patients undergoing chemotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
啊啾关注了科研通微信公众号
1秒前
多情听枫完成签到,获得积分10
2秒前
耶喽小黄完成签到 ,获得积分10
2秒前
圆圆完成签到 ,获得积分10
6秒前
小唐发布了新的文献求助10
7秒前
科研通AI2S应助神勇的香魔采纳,获得10
7秒前
今天又学明白了完成签到 ,获得积分10
8秒前
雨蒙蒙完成签到,获得积分10
8秒前
9秒前
12秒前
13秒前
英姑应助雨蒙蒙采纳,获得10
13秒前
lichengxun完成签到,获得积分20
14秒前
无花果应助正在努力的May采纳,获得10
14秒前
sping完成签到,获得积分10
15秒前
15秒前
15秒前
16秒前
薰硝壤应助lichengxun采纳,获得30
18秒前
18秒前
19秒前
19秒前
20秒前
爱与诚完成签到,获得积分10
21秒前
Lanx发布了新的文献求助10
21秒前
22秒前
K珑完成签到,获得积分10
23秒前
24秒前
25秒前
鸡鱼蚝发布了新的文献求助10
26秒前
爱与诚发布了新的文献求助30
26秒前
FashionBoy应助vv采纳,获得10
27秒前
洪栋国发布了新的文献求助10
28秒前
叶落知秋发布了新的文献求助10
28秒前
矮小的聪展完成签到,获得积分10
28秒前
打打应助喜乐采纳,获得10
29秒前
白敬亭发布了新的文献求助10
29秒前
30秒前
30秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
the women :a novel 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3055654
求助须知:如何正确求助?哪些是违规求助? 2712323
关于积分的说明 7430846
捐赠科研通 2357251
什么是DOI,文献DOI怎么找? 1248668
科研通“疑难数据库(出版商)”最低求助积分说明 606786
版权声明 596144