抗菌剂
纳米复合材料
阳离子聚合
沸石咪唑盐骨架
壳体(结构)
抗生素
咪唑酯
材料科学
化学
纳米技术
金属有机骨架
有机化学
高分子化学
吸附
生物化学
复合材料
作者
Qihui Kan,Yaping Song,Yining Yao,Jun Zhang,He Xian,Dan Cheng,Yue Wang,Liang Mao,Meiyan Wang,Chengzhong Yu
出处
期刊:Aggregate
[Wiley]
日期:2024-02-09
卷期号:5 (3)
摘要
Abstract Bacterial infection is a major threat to public health. Nanotechnology offers a solution by combining nanomaterials with antibacterial agents. The development of an effective nanocomposite against drug‐resistant bacteria such as methicillin‐resistant Staphylococcus aureus (MRSA) is highly important yet challenging. Here, an anti‐MRSA core–shell structure is designed, containing antibacterial zeolitic imidazolate framework‐8 (ZIF‐8) as the core and bactericidal benzalkonium chloride (BAC) templated rough‐surface mesostructured silica nanocomposite (RMSN) as the shell. The resultant ZIF‐8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions, effective disruption of the bacterial membrane, generation of oxidative damage of bacterial DNA, leakage of intracellular components, and finally bacterial death. Furthermore, the synergistic antibacterial mechanisms lead to enhanced biofilm elimination performance. In addition, the ZIF‐8@RMSN‐modified band‐aid effectively combats MRSA infection in vivo. This work has provided a promising nanocomposite against MRSA‐related infections.
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