Serum Creatinine–Cystatin C Based Screening of Sarcopenia in Community Dwelling Older Adults: A Cross-Sectional Analysis

肌萎缩 肌酐 胱抑素C 医学 逻辑回归 体质指数 接收机工作特性 横断面研究 内科学 老年学 胱抑素 病理
作者
Ryota Matsuzawa,Koutatsu Nagai,Keiichi Takahashi,Taisuke Mori,Masazumi Onishi,Shoji Tsuji,Kana Hashimoto,K. Tamaki,Yosuke Wada,Hiroshi Kusunoki,Yoshinobu Nagasawa,Ken Shinmura
出处
期刊:The Journal of frailty & aging [Springer Science+Business Media]
被引量:2
标识
DOI:10.14283/jfa.2024.13
摘要

To compare the discriminative capabilities for the manifestation of sarcopenia or physical frailty between serum creatinine- and cystatin C-derived indices among community-dwelling older adults. Cross-sectional study. Primary Care and Community. We utilized a subset of data from the Frail Elderly in the Sasayama-Tamba Area (FESTA) study, which was initiated in 2015 to gather comprehensive information on various health-related parameters among community-dwelling older individuals (age ≥65 years). Five serum creatinine–cystatin C based indices including the Sarcopenia Index, the serum creatinine/cystatin C ratio, the disparity between serum cystatin-C-based and creatinine-based estimated GFR, the total body muscle mass index (TBMM), and the prediction equation for skeletal muscle mass index (pSMI) were employed. Sarcopenia and physical frailty were identified based on the Asian Working Group for Sarcopenia criteria and the revised Japanese version of the Cardiovascular Health Study criteria, respectively. The receiver operating characteristic (ROC) and logistic regression analyses were performed to assess the discriminative abilities of these tools. In the analysis of 954 participants, 52 (5.5%) were identified with sarcopenia and 35 (3.7%) with physical frailty. Regarding sarcopenia discrimination, TBMM and pSMI both exhibited area under the curve (AUC) values exceeding 0.8 for both men and women. Concerning the identification of physical frailty, AUC values ranged from 0.61 to 0.77 for males and 0.50 to 0.69 for females. In the multivariate logistic regression analyses, only TBMM and pSMI consistently displayed associations with sarcopenia, irrespective of sex (P<0.001, respectively). On the other hand, no consistent associations were observed between the indices and physical frailty. This study provides a robust association of a serum creatinine- and cystatin C-derived indices, especially TBMM and pSMI, with sarcopenia among community-dwelling older adults. Conversely, the application of these indices for the screening of physical frailty has its constraints, necessitating further investigation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hello应助zhao采纳,获得10
刚刚
量子星尘发布了新的文献求助10
刚刚
1秒前
七日春信发布了新的文献求助10
4秒前
吴子宇发布了新的文献求助10
5秒前
journey完成签到 ,获得积分10
7秒前
10秒前
乖猫要努力应助潇湘雪月采纳,获得10
13秒前
一行发布了新的文献求助10
13秒前
storm完成签到,获得积分10
16秒前
HOPE完成签到,获得积分20
17秒前
Singularity应助Xiaoyang采纳,获得10
19秒前
ding应助快乐一江采纳,获得10
19秒前
20秒前
步一完成签到,获得积分10
21秒前
24秒前
情怀应助科研通管家采纳,获得10
24秒前
SYLH应助科研通管家采纳,获得10
24秒前
SYLH应助科研通管家采纳,获得10
25秒前
烟花应助科研通管家采纳,获得10
25秒前
在水一方应助科研通管家采纳,获得10
25秒前
dongjy应助科研通管家采纳,获得150
25秒前
Owen应助科研通管家采纳,获得10
25秒前
fd163c应助科研通管家采纳,获得10
25秒前
大模型应助科研通管家采纳,获得10
25秒前
SciGPT应助科研通管家采纳,获得10
25秒前
Owen应助科研通管家采纳,获得10
25秒前
25秒前
愉快的牛氓完成签到 ,获得积分10
27秒前
恋雅颖月应助潇湘雪月采纳,获得10
29秒前
31秒前
传奇3应助热情青亦采纳,获得10
32秒前
CodeCraft应助夕沫采纳,获得10
33秒前
江江发布了新的文献求助10
36秒前
斯文败类应助sirhai采纳,获得10
38秒前
只谈风月完成签到,获得积分10
39秒前
顾矜应助哈哈呵采纳,获得10
40秒前
科研助手6应助风中的南风采纳,获得10
40秒前
小马甲应助呆瓜采纳,获得10
40秒前
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174