转录组
髓样
肿瘤微环境
肺癌
表型
免疫学
计算生物学
生物
免疫系统
遗传学
基因
医学
肿瘤科
基因表达
作者
Lena Horvath,Constanze Puschmann,Alexandra Scheiber,Agnieszka Martowicz,Gregor Sturm,Zlatko Trajanoski,Dominik Wolf,Andreas Pircher,Stefan Salcher
标识
DOI:10.1016/j.trecan.2024.01.010
摘要
Neutrophils represent the most abundant myeloid cell subtype in the non-small-cell lung cancer (NSCLC) tumor microenvironment (TME). By anti- or protumor polarization, they impact multiple aspects of tumor biology and affect sensitivity to conventional therapies and immunotherapies. Single-cell RNA sequencing (scRNA-seq) analyses have unraveled an extensive neutrophil heterogeneity, helping our understanding of their pleiotropic role. In this review we summarize recent data and models on tumor-associated neutrophil (TAN) biology, focusing on the diversity that evolves in response to tumor-intrinsic cues. We categorize available transcriptomic profiles from different cancer entities into a defined set of neutrophil subclusters with distinct phenotypic properties, to step beyond the traditional binary N1/2 classification. Finally, we discuss potential ways to exploit these neutrophil states in the setting of anticancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI