内分泌学
内科学
肾
医学
受体
肾功能
导管(解剖学)
肾素-血管紧张素系统
病理
血压
作者
Gertrude Arthur,Audrey Poupeau,Karl Y. Biel,Jeffrey L. Osborn,Ming Gong,Terry D. Hinds,Volkhard Lindner,Analia S. Loria
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2024-04-01
卷期号:326 (4): F611-F621
标识
DOI:10.1152/ajprenal.00375.2023
摘要
We successfully generated a humanized mouse model that expresses human sPRR in the collecting duct. Collecting duct-derived human sPRR did not change circulating sPRR and RAS levels but increased daytime BP in female mice while showing an attenuated angiotensin II-dependent pressor response. These findings may aid in elucidating the mechanisms by which women show uncontrolled BP in response to antihypertensive treatments targeting the RAS, improving approaches to reduce uncontrolled BP and chronic kidney disease incidences in women.
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