Histone chaperones: A multinodal highway network inside the cell

Histone chaperones participate in the biogenesis, transportation, and deposition of histones. They contribute to processes impacted by nucleosomes including DNA replication, transcription, and epigenetic inheritance. In this issue, Carraro et al. 1 Carraro M., Hendriks I.A., Hammond C.M., Solis-Mezarino V., Völker-Albert M., Elsborg J.D., Weisser M.B., Spanos C., Montoya G., Rappsilber J., et al. DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network. Mol. Cell. Published online March 2, 2023. https://doi.org/10.1016/j.molcel.2023.02.009. Google Scholar reveal an interconnected chaperone network and a surprising function of histone chaperone DAXX in de novo deposition of H3.3K9me3. Histone chaperones participate in the biogenesis, transportation, and deposition of histones. They contribute to processes impacted by nucleosomes including DNA replication, transcription, and epigenetic inheritance. In this issue, Carraro et al. 1 Carraro M., Hendriks I.A., Hammond C.M., Solis-Mezarino V., Völker-Albert M., Elsborg J.D., Weisser M.B., Spanos C., Montoya G., Rappsilber J., et al. DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network. Mol. Cell. Published online March 2, 2023. https://doi.org/10.1016/j.molcel.2023.02.009. Google Scholar reveal an interconnected chaperone network and a surprising function of histone chaperone DAXX in de novo deposition of H3.3K9me3.