Insulin resistance is more frequent in type 1 diabetes patients with long disease duration

医学 胰岛素抵抗 内科学 糖尿病 血脂异常 1型糖尿病 代谢综合征 内分泌学 肥胖 队列 2型糖尿病 胃肠病学
作者
Yuting Xie,Mei Shi,Xiaolin Ji,Fansu Huang,Li Fan,Xia Li,Zhiguang Zhou
出处
期刊:Diabetes-metabolism Research and Reviews [Wiley]
卷期号:39 (6) 被引量:4
标识
DOI:10.1002/dmrr.3640
摘要

Abstract Aims To investigate the clinical status of insulin resistance (IR) and its correlation with disease duration in patients with type 1 diabetes (T1D). Materials and Methods Cross‐sectional data from a T1D cohort were obtained ( n = 923). IR‐related metabolic disorders including hypertension, obesity, and dyslipidemia were used as outcome variables to explore the cut‐off point for estimated glucose disposal rate (eGDR) by restricted cubic spline (RCS) curve. Regression models were used for multivariate analysis of the clinical factors associated with IR. The correlation between the status of IR and diabetes duration was depicted with the RCS curve. Results IR‐related metabolic disorders were observed in 39.4% of patients, with 9.1% meeting the criteria for metabolic syndrome. Specifically, patients with ≥10 years of T1D were more likely to have IR‐related metabolic disorders (54.7% vs. 36.9%, p < 0.05). The presence of IR, defined as an eGDR ≤9.0 mg/kg/min, was observed in 42.2% of patients. Patients with IR had a longer diabetes duration (3.5 vs. 2.7, years, p = 0.003) and higher insulin dose (0.5 vs. 0.4, units per kg per day, p < 0.001). Moreover, the presence of IR showed a gradual increase during 10 years' disease duration and further analysis showed that diabetes duration ≥10 years was a key element behind the development of IR and IR‐related metabolic disorders. Conclusions The status of IR is common in T1D patients, especially in those with ≥10 years of disease duration. Therapies targeting balancing glycaemic control and IR are needed to decrease the future risk of cardiovascular diseases in T1D. Clinical trial registration: ClinicalTrials.gov NCT03610984 (cohort study of patients with type 1 diabetes).
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