The mechanical advancement in conventional origami metamaterials is limited since only single layer exists at a deterministic scale. In this paper, the bio-inspired dual-layer origami (BDO) metamaterials is proposed, involving a couple of nested origami layers connected by the bio-inspired ribs. Sudoku-inspired surrogate models are developed for design parameters to tailor the mechanical performance of BDO. The multi-objective optimization reveals that the BDO metamaterials exhibit superior mechanical performance compared with the conventional single-layer origami metamaterial since the strong interaction between the ribs and layers. The energy absorption capacity of the optimal BDO is improved by 59.45%. Moreover, a performance-oriented parameter selection system for BDO is established, facilitating the application of origami metamaterials in a wide range of protective and load-bearing scenarios.