Synthesis of chiral 2‐trifluoromethyl‐4‐(tetrahydroquinolinyl)‐4H‐chromenes via Pd‐catalyzed asymmetric amination

A new strategy for the construction of chiral 4H‐chromene skeleton via Pd‐catalyzed asymmetric amination of 2H‐chromene was reported. A series of chiral 2‐trifluoromethyl‐4H‐chromenes containing 1,2,3,4‐tetrahydroquinoline unit were synthesized in moderate to good yields with excellent enantioselectivity, the method serves as an effective supplement to the construction of chiral 4H‐chromene skeleton.