多克隆抗体
加合物
生物
碱基
抗原
分子生物学
生物化学
遗传学
DNA
化学
有机化学
作者
Andrew Chancellor,Daniel Constantin,Giuliano Berloffa,Qinmei Yang,Vladimir Nosi,José Pedro Loureiro,Rodrigo Colombo,R.P. Jakob,Daniel Joss,Michael Pfeffer,Giulia De Simone,Aurelia Morabito,Verena Schaefer,Alessandro Vacchini,Laura Brunelli,Daniela Montagna,Markus H. Heim,Alfred Zippelius,Enrico Davoli,Daniel Häußinger,Timm Maier,Lucia Mori,Gennaro De Libero
标识
DOI：10.1016/j.immuni.2024.11.019
摘要
The major histocompatibility complex (MHC) class I-related molecule MHC-class-I-related protein 1 (MR1) presents metabolites to distinct MR1-restricted T cell subsets, including mucosal-associated invariant T (MAIT) and MR1T cells. However, self-reactive MR1T cells and the nature of recognized antigens remain underexplored. Here, we report a cell endogenous carbonyl adduct of adenine (8-(9H-purin-6-yl)-2-oxa-8-azabicyclo[3.3.1]nona-3,6-diene-4,6-dicarbaldehyde [M
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