Radiation Recall Mucositis in Immunotherapy: A Road We've Traveled

Radiation recall mucositis (RRM) 1 Wu Y Qian Y Treatment for radiation-recall mucositis induced by anti-PD-1 blockade. Int J Radiat Oncol Biol Phys. 2023; 115: 7-8 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar rarely occurs in immunotherapy and the mechanisms of RRM are unclear. With reference to immune-related organ damage, we hypothesized that radiation therapy results in altered nasopharyngeal microenvironment and tumor cell antigen exposure, which leads to an overwhelming local inflammatory response and potentially RRM in nasopharyngeal during immunotherapy. Treatment for Radiation-Recall Mucositis Induced by Anti-PD-1 BlockadeInternational Journal of Radiation Oncology, Biology, PhysicsVol. 115Issue 1PreviewWe report 3 cases of radiation recall mucositis (RRM) induced by immunotherapy. Mr Z with nasopharyngeal carcinoma was first treated by radiation therapy and administrated with immunotherapy and chemotherapy when disease progressed with lung metastases (Fig. 1 A). A very good partial response was observed but the nasopharyngoscope revealed mucositis in the irradiated area where radiation therapy was applied 43 months ago (Fig. 2 A-C). Mucositis initially caused by radiation but recalled by immunotherapy is RRM. Full-Text PDF