Heart failure related central sympathetic activation: debunking the ‘holy grail’?

European Journal of Heart FailureVolume 25, Issue 2 p. 211-212 Invited Editorial Heart failure related central sympathetic activation: debunking the ‘holy grail’? Guido Grassi, Corresponding Author Guido Grassi [email protected] Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Milan, Italy Corresponding author. Clinica Medica, University Milano-Bicocca, Via Pergolesi 33, 20052 Monza, Italy. Email: [email protected]Search for more papers by this author Guido Grassi, Corresponding Author Guido Grassi [email protected] Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Milan, Italy Corresponding author. Clinica Medica, University Milano-Bicocca, Via Pergolesi 33, 20052 Monza, Italy. Email: [email protected]Search for more papers by this author First published: 04 January 2023 https://doi.org/10.1002/ejhf.2764 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.2749. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1Floras JS, Ponikowski P. The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction. Eur Heart J. 2015; 36: 1974– 82b. 2Grassi G, Mancia G, Esler M. Central and peripheral sympathetic activation in heart failure. Cardiovasc Res. 2022; 118: 1857– 71. 3Omerovic E, Citro R, Bossone E, Redfors B, Backs J, Bruns B, et al. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 1: overview and the central role for catecholamines and sympathetic nervous system. Eur J Heart Fail. 2022; 24: 257– 73. 4Thomas JA, Marks BH. Plasma norepinephrine in congestive heart failure. Am J Cardiol. 1978; 41: 233– 43. 5Grassi G, Quarti-Trevano F, Esler MD. Sympathetic activation in congestive heart failure:an updated overview. Heart Fail Rev. 2021; 26: 173– 82. 6Cohn J, Levine T, Olivari MT, Garberg V, Tura D, Francis GS, et al. Plasma norepinephrine as a guide to prognosis in patients with congestive heart failure. N Engl J Med. 1984; 311: 819– 23. 7Badrov MD, Keir DA, Tomlison G, Notarius CF, Millar PJ, Kimmerly DS, et al. Normal and excessive muscle symapthetic nerve activity: implications for future trials of therapeutic autonomic modulation. Eur J Heart Fail. 2023; 25: 201– 10. 8Van Bilsen M, Patel HC, Bauersachs J, Böhm M, Borggrefe M, Brutsaert D, et al. The autonomic nervous system as a therapeutic target in heart failure: a scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2017; 19: 1361– 78. 9Grassi G, Seravalle G, Cattaneo BM, Lanfranchi A, Vailati S, Giannattasio C, et al. Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation. 1995; 92: 3206– 11. 10Rundqvist B, Elam M, Bergmann-Sverrisdottir Y, Eisenhofer G, Friberg P. Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure. Circulation. 1997; 95: 169– 75. 11Grassi G, D'Arrigo G, Pisano A, Bolignano D, Mallamaci F, Dell'Oro R, et al. Sympathetic neural overdrive in congestive heart failure and its correlates: systematic reviews and meta-analysis. J Hypertens. 2019; 37: 1746– 56. 12Grassi G, Pisano A, Bolignano D, Seravalle G, D'Arrigo G, Quarti-Trevano F, et al. Sympathetic nerve traffic activation in essential hypertension and its correlates. Systematic reviews and meta-analyses. Hypertension. 2018; 72: 483– 91. 13Grassi G, Biffi A, Quarti Trevano F, Dell'Oro R, Corrao G, Mancia G. Sympathetic neural overdrive in the obese and overweight state: meta-analysis of published studies. Hypertension. 2019; 74: 369– 8. 14Hasking G, Esler M, Jennings G, Burton D, Johns J, Korner P. Norepinephrine spillover to plasma in congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation. 1988; 73: 615– 21. Volume25, Issue2February 2023Pages 211-212 ReferencesRelatedInformation