抗辐射性
辐射敏感性
宫颈癌
放射治疗
癌症
癌症研究
医学
肿瘤科
前列腺癌
疾病
DNA修复
小RNA
癌症干细胞
生物信息学
生物
内科学
DNA
遗传学
基因
作者
Shuying Wu,He Zhu,Yishi Wu,Cong Wang,Xuefeng Duan,Tianmin Xu
标识
DOI:10.3389/fgene.2022.1093549
摘要
Despite advances in cervical cancer screening and human papilloma virus (HPV) vaccines, cervical cancer remains a global health burden. The standard treatment of cervical cancer includes surgery, radiation therapy, and chemotherapy. Radiotherapy (RT) is the primary treatment for advanced-stage disease. However, due to radioresistance, most patients in the advanced stage have an adverse outcome. Recent studies have shown that long noncoding RNAs (lncRNAs) participate in the regulation of cancer radiosensitivity by regulating DNA damage repair, apoptosis, cancer stem cells (CSCs), and epithelial–mesenchymal transition (EMT). In this review, we summarize the molecular mechanisms of long noncoding RNAs in cervical cancer and radiosensitivity, hoping to provide a theoretical basis and a new molecular target for the cervical cancer RT in the clinic.
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