医学
血脂异常
他汀类
危险系数
内科学
倾向得分匹配
回顾性队列研究
糖尿病
骨质疏松症
人口
2型糖尿病
髋部骨折
物理疗法
内分泌学
疾病
置信区间
环境卫生
作者
Tien‐Ching Lee,Jian‐Chih Chen,Sung‐Yen Lin,Pei‐Shan Ho,Chung‐Hwan Chen,Yin‐Chih Fu,Je‐Ken Chang,Mei‐Ling Ho
摘要
Type 2 diabetes mellitus (T2DM) frequently co-exists with osteoporosis and dyslipidemia. Statins have been commonly used in the treatment of dyslipidemia. Recent studies have indicated a therapeutic role of statins in decreasing the risk of osteoporosis and fractures, but conflicting results have been reported. This study investigated the association between statin use and hip fracture (HFx) risk among T2DM patients.A retrospective Taiwan population-based propensity-matched cohort study was performed using the Diabetes Mellitus Health Database from Taiwan National Health Insurance Research Database. Patients with newly diagnosed with T2DM between 2010 and 2014 were identified. Patients who previously used statins and had ever suffered HFx before the index date were excluded. HFx that occurred from 2010 to 2019 was collected to compute the cumulative rate of HFx. Hazard ratios (HRs) were calculated for the HFx risk according to the use or non-use of statins. To evaluate the dose-effect relationship of statins, sensitivity analyses were conducted.After propensity score matching for age and sex, 188,588 patients were identified as statin users and non-statin users. Statin use after T2DM diagnosis was associated with a decreased HFx risk with an adjusted HR (aHR) of 0.69 (P < 0.001). A dose-effect relationship was identified. The aHRs for developing HFx were 1.29, 0.67, and 0.36 for patients who used 28-174, 175-447, and >447 cumulative defined daily doses of statins, respectively (P < 0.001).Statin use in adults with T2DM showed a lower risk of HFx by demonstrating a dose-response relationship.
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