Morinda citrifolia Extract Prevents Alcoholic Fatty Liver Disease by Improving Gut Health

肠道菌群 脂肪肝 酒精性肝病 失调 氧化应激 炎症 脂质代谢 脂肪性肝炎 脂肪生成 内科学 内分泌学 生物 化学 药理学 医学 免疫学 肝硬化 疾病
作者
Moon Ho,Hyun Hee L. Lee,Miri Park,Min Seok Oh,Eunjung Lee,Minson Kweon,Ho‐Young Park
出处
期刊:Journal of Medicinal Food [Mary Ann Liebert]
卷期号:25 (12): 1102-1111 被引量:2
标识
DOI:10.1089/jmf.2022.k.0056
摘要

Alcoholic liver disease (ALD) is a major chronic liver disease. Chronic alcohol consumption induces dysbiosis, disruption of gut barrier function, oxidative stress, inflammation, and changes in lipid metabolism, thereby leading to ALD. In this study, we investigated whether the commercial Morinda citrifolia extract Nonitri can ameliorate ALD symptoms through the gut-liver axis. We used mice chronically administered EtOH and found a marked increase in serum endotoxin levels and biomarkers of liver pathology. Moreover, the EtOH-treated group showed significantly altered gut microbial composition particularly that of Alistipes, Bacteroides, and Muribaculum and disrupted gut barrier function. However, Nonitri improved serum parameters, restored the microbial proportions, and regulated levels of zonula occludens1, occludin, and claudin1. Furthermore, Nonitri suppressed inflammation by inhibiting endotoxin-triggered toll-like receptor 4-signaling pathway and fat deposition by reducing lipogenesis through activating AMP-activated protein kinase in the liver. Furthermore, Pearson's correlation analysis showed that gut microbiota and ALD-related markers were correlated, and Nonitri regulated these bacteria. Taken together, our results indicate that the hepatoprotective effect of Nonitri reduces endotoxin levels by improving gut health, and inhibits fat deposition by regulating lipid metabolism.
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