孟德尔随机化
观察研究
混淆
儿童白血病
医学
胎龄
出生体重
儿科
随机化
怀孕
随机对照试验
产科
白血病
淋巴细胞白血病
内科学
生物
遗传学
遗传变异
基因
基因型
作者
Tormod Rogne,Andrew T. DeWan,Catherine Metayer,Joseph L. Wiemels,Xiaomei Ma
标识
DOI:10.1016/j.ajogmf.2023.101058
摘要
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and the incidence is increasing.1 Albeit inconsistently, birthweight and gestational age at birth – particularly high birthweight and preterm birth – have been linked to risk of childhood ALL in observational studies, which has been hypothesized to be in part due to intrauterine exposure to growth factors (high birthweight) and immature immune system and antioxidant defense system (preterm birth).2–4 A potential limitation with traditional observational studies is residual confounding. Because genetic variants are allocated at random at conception, they may be used as instrumental variables to assess the unconfounded effect of an exposure on an outcome (mimicking a randomized experiment), often referred to as “Mendelian randomization” (MR) (Supplementary Figure).5 We aimed to evaluate the potential association between genetically-predicted birthweight and gestational duration, and the risk of childhood ALL by conducting a two-sample MR study.
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