组蛋白H4
乙酰化
组蛋白乙酰转移酶
组蛋白
染色质
组蛋白密码
染色质重塑
组蛋白甲基转移酶
生物
细胞生物学
化学
生物化学
核小体
基因
作者
Qiutao Xu,Yaping Yue,B.-R. Liu,Zhengting Chen,Xuan Ma,Jing Wang,Yu Zhao,Dao‐Xiu Zhou
标识
DOI:10.1038/s41467-023-39101-4
摘要
Abstract Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear. Here we show that ACL subunit A2 (ACLA2) is present in nuclear condensates, is required for nuclear acetyl-CoA accumulation and acetylation of specific histone lysine residues, and interacts with Histone AcetylTransferase1 (HAT1) in rice. The rice HAT1 acetylates histone H4K5 and H4K16 and its activity on H4K5 requires ACLA2. Mutations of rice ACLA2 and HAT1 ( HAG704 ) genes impair cell division in developing endosperm, result in decreases of H4K5 acetylation at largely the same genomic regions, affect the expression of similar sets of genes, and lead to cell cycle S phase stagnation in the endosperm dividing nuclei. These results indicate that the HAT1-ACLA2 module selectively promotes histone lysine acetylation in specific genomic regions and unravel a mechanism of local acetyl-CoA production which couples energy metabolism with cell division.
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