Palladium/copper-cocatalyzed three-component tandem cyclization of o-alkenyl arylisocyanides, sulfur ylides with alcohols: direct synthesis of spiro 3,3’-cyclopropyl oxindoles

A novel palladium/copper-cocatalyzed tandem cyclization of o -alkenyl arylisocyanides and sulfur ylides with alcohols has been developed, providing a simple and efficient method for the synthesis of spiro 3,3′-cyclopropyl oxindoles in a single step.