Blood sphingolipid as a novel biomarker in patients with neuromyelitis optica spectrum disorder

鞘脂 视神经脊髓炎 医学 多发性硬化 生物标志物 扩大残疾状况量表 免疫学 内科学 生物 生物化学
作者
Hyun‐Jin Kim,Hwa Jung Kim,Jungmin So,Ji Yon Kim,Hee-Jae Jung,Seungmi Kim,Dayoung Seo,Hyunji Kim,Ha Eun Song,Young‐Min Lim,Hyun Ju Yoo,Eun‐Jae Lee
出处
期刊:Multiple sclerosis and related disorders [Elsevier BV]
卷期号:85: 105551-105551
标识
DOI:10.1016/j.msard.2024.105551
摘要

Abstract

Background

Sphingolipids are signaling molecules and structural components of the axolemma and myelin sheath. Plasma sphingolipid levels may reflect disease status of neuromyelitis optica spectrum disorder (NMOSD). We aimed to examine plasma sphingolipids as disease severity biomarkers for NMOSD and compare their characteristics with those of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP).

Methods

We measured plasma sphingolipids, sNfL, and sGFAP levels in NMOSD cases with anti-aquaporin-4-antibody. An unbiased approach, partial least square discriminant analysis (PLS-DA), was utilized to determine whether sphingolipid profiles differ according to the disease state of NMOSD (presence, moderate-to-severe disability [Expanded Disease Severity Scale, (EDSS) > 3.0], and relapses).

Results

We investigated 81 patients and 10 controls. PLS-DA models utilizing sphingolipids successfully differentiated patients with EDSS > 3.0, but failed to identify the presence of disease and relapses. Ceramide-C14—a significant contributor to differentiating EDSS > 3.0—positively correlated with EDSS, while its levels were independent of age and the presence of relapses. This characteristic was unique from those of sNfL and sGFAP, which were affected by age and relapses as well as EDSS.

Conclusion

Plasma sphingolipids may be useful NMOSD biomarkers for disability with distinct characteristics compared to sNfL and sGFAP.
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