腐胺
亚精胺
尸体
多胺
秀丽隐杆线虫
生物
趋化性
粪肠球菌
大肠杆菌
精胺
细菌
微生物学
生物化学
遗传学
基因
酶
受体
作者
Benjamin Brissette,Lia Ficaro,Chenguang Li,Drew R. Jones,Sharad Ramanathan,Niels Ringstad
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-03-22
卷期号:10 (12)
标识
DOI:10.1126/sciadv.adj4387
摘要
Much is known about molecular mechanisms by which animals detect pathogenic microbes, but how animals sense beneficial microbes remains poorly understood. The roundworm Caenorhabditis elegans is a microbivore that must distinguish nutritive microbes from pathogens. We characterized a neural circuit used by C. elegans to rapidly discriminate between nutritive bacteria and pathogens. Distinct sensory neuron populations responded to chemical cues from nutritive Escherichia coli and pathogenic Enterococcus faecalis , and these neural signals are decoded by downstream AIB interneurons. The polyamine metabolites cadaverine, putrescine, and spermidine produced by E. coli activate this neural circuit and elicit positive chemotaxis. Our study shows how polyamine odorants can be sensed by animals as proxies for microbe identity and suggests that, hence, polyamines might have widespread roles brokering host-microbe interactions.
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