脂肪肝
信号转导
肢端肥大症
内分泌学
侏儒症
内科学
医学
肝病
生长因子
激素
生长激素
癌症研究
生物
生物信息学
疾病
受体
基因
细胞生物学
遗传学
作者
Madisyn Oxley,Heather Francis,Keisaku Sato
出处
期刊:Seminars in Liver Disease
[Georg Thieme Verlag KG]
日期:2023-01-18
卷期号:43 (01): 024-030
被引量:7
摘要
Growth hormone (GH) and downstream insulin-like growth factor 1 (IGF1) signaling mediate growth and metabolism. GH deficiency causes short stature or dwarfism, and excess GH causes acromegaly. Although the association of GH/IGF1 signaling with liver diseases has been suggested previously, current studies are controversial and the functional roles of GH/IGF1 signaling are still undefined. GH supplementation therapy showed promising therapeutic effects in some patients, such as non-alcoholic fatty liver disease, but inhibition of GH signaling may be beneficial for other liver diseases, such as hepatocellular carcinoma. The functional roles of GH/IGF1 signaling and the effects of agonists/antagonists targeting this signaling may differ depending on the liver injury or animal models. This review summarizes current controversial studies of GH/IGF1 signaling in liver diseases and discusses therapeutic potentials of GH therapy.
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