Circadian rhythm of carbohydrate metabolism in health and disease

昼夜节律 内分泌学 内科学 碳水化合物代谢 生物 褪黑素 葡萄糖稳态 肥胖 糖尿病 胰岛素抵抗 医学
作者
M. Yu. Sorokin,Б. Б. Пинхасов,V. G. Selyatitskaya
出处
期刊:Acta biomedica scientifica [FSPSI SCFHHRP]
卷期号:8 (2): 124-137 被引量:1
标识
DOI:10.29413/abs.2023-8.2.12
摘要

The article presents a review of the main circadian mechanisms regulating carbohydrate metabolism and their role in maintenance of energy homeostasis; the molecular genetic structure of the circadian system is also discussed. The role of adipose tissue and other organs and systems in the maintenance of circadian rhythm of carbohydrate metabolism, both in health and in obesity and diabetes, is highlighted. Particular attention is paid to diurnal rhythms of endocrine factors responsible for metabolic patterns of hormones such as cortisol, growth hormone and melatonin. Gender differences in the circadian regulation of energy and carbohydrate metabolism are also discussed, as well as their changes in different age periods. Article provides detailed review of the mechanisms of glucose utilization, reactivity of the pancreatic islets and peripheral insulin sensitivity shifts at different time periods of the day in people with normal body weight, android and gynoid types of obesity, both in women and men. Protective factors of energy metabolism circadian regulation structure preventing the development of diabetes mellitus and cardiovascular disease in individuals with so-called “metabolically healthy” obesity type are discussed. Article provides a review of various pathways of circadian rhythm disturbances, mechanisms of their development, as well as exogenous and endogenous factors leading to carbohydrate metabolic circadian rhythm misalignment, such as shift work, untiming of natural and artificial lighting, jet lags, sleep disorders. Represented data contribute to a new look at the pathogenesis of obesity and carbohydrate metabolism disorders in various types of obesity in men and women, that provides basis for searching for new effective methods of prevention and treatment of these conditions, elaboration of evidence-based diets and physical activity recommendations, as well as approaches to their medical treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
成帅哥完成签到,获得积分10
1秒前
怦然心动发布了新的文献求助10
1秒前
2秒前
2秒前
西南雪豹发布了新的文献求助10
2秒前
2秒前
PPP发布了新的文献求助10
2秒前
FashionBoy应助沙子1022采纳,获得10
3秒前
4秒前
桥抱千嶂完成签到,获得积分10
4秒前
清脆的土豆应助TN采纳,获得10
4秒前
4秒前
550发布了新的文献求助10
5秒前
莹仔发布了新的文献求助10
5秒前
Rui完成签到,获得积分10
6秒前
水1111完成签到,获得积分10
6秒前
小夫发布了新的文献求助10
7秒前
Detoxicate发布了新的文献求助10
7秒前
852应助阿泽采纳,获得10
7秒前
古月博士发布了新的文献求助10
8秒前
水1111发布了新的文献求助10
8秒前
爱静静应助龙龙采纳,获得30
9秒前
9秒前
打打应助yyyq0721采纳,获得10
9秒前
小程同学发布了新的文献求助10
11秒前
PPP完成签到,获得积分10
11秒前
雪茶完成签到,获得积分10
11秒前
Hastur00发布了新的文献求助10
12秒前
hy完成签到,获得积分10
12秒前
专注垣发布了新的文献求助10
13秒前
Fjj完成签到,获得积分10
13秒前
abner完成签到,获得积分10
14秒前
Jasper应助11采纳,获得10
14秒前
15秒前
朕的天下发布了新的文献求助10
15秒前
kiminonawa应助飘逸宛丝采纳,获得10
15秒前
研友_VZG7GZ应助科研通管家采纳,获得10
16秒前
Gtpangda应助科研通管家采纳,获得10
16秒前
田様应助科研通管家采纳,获得10
16秒前
桐桐应助科研通管家采纳,获得10
16秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
SIS-ISO/IEC TS 27100:2024 Information technology — Cybersecurity — Overview and concepts (ISO/IEC TS 27100:2020, IDT)(Swedish Standard) 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Semiconductor Process Reliability in Practice 720
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3231938
求助须知:如何正确求助?哪些是违规求助? 2878924
关于积分的说明 8208328
捐赠科研通 2546436
什么是DOI,文献DOI怎么找? 1375933
科研通“疑难数据库(出版商)”最低求助积分说明 647489
邀请新用户注册赠送积分活动 622660