Genetically determined iron status was associated with polymyalgia rheumatica but not with giant cell arteritis: A Mendelian randomization analysis

International Journal of Rheumatic DiseasesEarly View CORRESPONDENCE Genetically determined iron status was associated with polymyalgia rheumatica but not with giant cell arteritis: A Mendelian randomization analysis Xun Xiao, Xun Xiao Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaSearch for more papers by this authorShizhen Li, Corresponding Author Shizhen Li [email protected] orcid.org/0009-0006-4856-0818 Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Correspondence Shizhen Li, Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Email: [email protected]Search for more papers by this author Xun Xiao, Xun Xiao Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaSearch for more papers by this authorShizhen Li, Corresponding Author Shizhen Li [email protected] orcid.org/0009-0006-4856-0818 Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Correspondence Shizhen Li, Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Email: [email protected]Search for more papers by this author First published: 21 July 2023 https://doi.org/10.1111/1756-185X.14841Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Open Research DATA AVAILABILITY STATEMENT The data that support the findings of this study are available in FinnGen consortium at https://r5.finngen.fi/. These data were derived from the following resources available in the public domain: FinnGen consortium, https://r5.finngen.fi/ and Genetics of Iron Status Consortium, https://gwas.mrcieu.ac.uk/. Supporting Information Filename Description apl14841-sup-0001-supinfo.docxWord 2007 document , 141.4 KB Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Lundberg IE, Sharma A, Turesson C, Mohammad AJ. An update on polymyalgia rheumatica. J Intern Med. 2022; 292(5): 717-732. 2Garvey TD, Koster MJ, Warrington KJ. My treatment approach to giant cell arteritis. Mayo Clin Proc. 2021; 96(6): 1530-1545. 3Salvarani C, Cantini F, Boiardi L, Hunder GG. Polymyalgia rheumatica and giant-cell arteritis. N Engl J Med. 2002; 347(4): 261-271. 4Buttgereit F, Dejaco C, Matteson EL, Dasgupta B. Polymyalgia rheumatica and giant cell arteritis: A systematic review. JAMA. 2016; 315(22): 2442-2458. 5Man-Ger SM, Pope JE. Unmet need in the treatment of polymyalgia rheumatica and giant cell arteritis. Best Pract Res Clin Rheumatol. 2023; 36:101822. 6Sekula P, Del GMF, Pattaro C, Köttgen A. Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol. 2016; 27(11): 3253-3265. 7Yuan S, Larsson S. Causal associations of iron status with gout and rheumatoid arthritis, but not with inflammatory bowel disease. Clin Nutr. 2020; 39(10): 3119-3124. 8Xu J, Zhang S, Tian Y, et al. Genetic causal association between iron status and osteoarthritis: A two-sample Mendelian randomization. Nutrients. 2022; 14(18): 3683. 9Qu Z, Yang F, Hong J, et al. Causal relationship of serum nutritional factors with osteoarthritis: A Mendelian randomization study. Rheumatology (Oxford). 2021; 60(5): 2383-2390. 10Pereira M, Kaine JL. Polymyalgia rheumatica and temporal arteritis: managing older patients. Geriatrics. 1986; 41(6): 54-55. 59-60, 63 passim. 11Nesher G, Breuer GS. Giant Cell Arteritis and Polymyalgia Rheumatica: 2016 Update. Rambam Maimonides Med J. 2016; 7(4):e0035. 12Baerlecken NT, Linnemann A, Gross WL, et al. Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica. Ann Rheum Dis. 2012; 71(6): 943-947. 13Tamosauskaite J, Atkins JL, Pilling LC, et al. Hereditary hemochromatosis associations with frailty, sarcopenia and chronic pain: evidence from 200,975 Older UK biobank participants. J Gerontol A Biol Sci Med Sci. 2019; 74(3): 337-342. 14Ni S, Yuan Y, Kuang Y, Li X. Iron metabolism and immune regulation. Front Immunol. 2022; 13:816282. 15Carvajal AG, Boukhlal S, Cornec D, Devauchelle-Pensec V. The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle. Autoimmun Rev. 2020; 19(11):102670. 16Hysa E, Gotelli E, Sammorì S, et al. Immune system activation in polymyalgia rheumatica: Which balance between autoinflammation and autoimmunity? A systematic review. Autoimmun Rev. 2022; 21(2):102995. 17Martins AC, Almeida JI, Lima IS, Kapitão AS, Gozzelino R. Iron metabolism and the inflammatory response. Iubmb Life. 2017; 69(6): 442-450. 18Baker JF, Ghio AJ. Iron homoeostasis in rheumatic disease. Rheumatology (Oxford). 2009; 48(11): 1339-1344. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation