共轭体系
催化作用
化学
组合化学
立体化学
有机化学
聚合物
作者
Jiguo Ma,Jingui Duan,Zhi‐Xiang Yu
出处
期刊:PubMed
日期:2024-09-15
卷期号:: e202417407-e202417407
标识
DOI:10.1002/anie.202417407
摘要
We report here the first nickel-catalyzed rearrangement of vinylcyclobutanones (VCBOs) under mild conditions to synthesize non-conjugated cyclohexenone derivatives, which so far do not have many ways to be accessed. The reaction exhibits a wide substrate scope with reaction yields up to 98%. This VCBO rearrangement can also be used to access various n/6 (n = 5-8) bicyclic products efficiently. Furthermore, mechanism of this rearrangement has been investigated using DFT calculations, showing that vinyl group-assisted cyclobutanone C-C cleavage is easy with a computed activation free energy of 18.1 kcal/mol.
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